Guest blog post by Godfrey Oakley, M.D., Research Professor of Epidemiology with Emory University
With a focused, well-planned, and well-financed immunization program led by the Global Polio Eradication Initiative, we have seen the number of polio cases reported worldwide decline from 350,000 in 1988 to 1,604 in 2009. I hope the birth defects prevention and nutrition communities will harness similar energies to prevent the 200,000 fatal or permanently disabling birth defects that could be prevented with folic acid.
Spina bifida and anencephaly are the most common forms of neural tube defects (NTDs). The March of Dimes estimates that 300,000 NTDs occur every year, but 50 to 70 percent of these could be prevented if the mother has enough vitamin B 9, known as folic acid, at least a month before she conceives and early in her pregnancy.
While polio is an infectious disease caused by a virus, and preventable spina bifida and anencephaly are caused by insufficient folic acid, there are at least three parallels between polio and folic acid-preventable NTDs:
- Both can be prevented. Folic acid-preventable NTDs can be totally eliminated by providing enough folic acid to women who may become pregnant.
- Both can be paralyzing. In cases of spina bifida, the spinal cord does not form correctly and individuals are often confined to a wheelchair for a lifetime. Additionally, almost all individuals with spina bifida have paralysis of bowel and bladder and most have significant paralysis of motor functions for the lower body.
- Both can be fatal. NTDs that affect formation of the brain, called anencephaly, are always fatal. Spina bifida may also be fatal especially where there is no access to specialized surgical and other treatment.
While polio eradication requires individually immunizing the population, many cases of NTDs can be prevented by fortifying commonly consumed foods with folic acid. In the early 1990s, I worked with the March of Dimes and other partners to get enriched cereal grains in the United States fortified with folic acid. The regulation for this was passed in 1996 and full implemented by January 1, 1998.
The U.S. Centers for Disease Control and Prevention (CDC) calls the resulting 36% decline in NTDs one of the “great public health achievements.” The CDC estimates that 1,000 NTDs are prevented in the U.S. annually due to fortification. Since the U.S. has been fortifying for 13 years, that’s 13,000 birth defects prevented. These actions have saved more than $5 billion dollars in direct cost.
Some people say that encouraging women who might become pregnant to take folic acid supplements is a better strategy. This would be a sufficient strategy if every pregnancy were planned, if every woman knew to take folic acid supplements, if every woman could afford the supplements, and if every woman remembered to take them daily.
Countries that rely only on a supplementation program to prevent NTDs typically find that it fails to reach at least 50 percent of the women of reproductive age. Let’s accept the reality that supplement programs should complement a mandatory folic acid fortification of grain such as flour, not serve as a stand-alone strategy because they will fail half of the population.
Other people will argue that people should get their supply of folic acid from natural food sources. The problem is that foods contain such little amounts of vitamin B9 that it’s hard to get the recommend 400 micrograms from unfortified foods alone. For a woman to get enough folate from non-fortified foods she would have to eat four slices of beef liver or 200 medium red applies or 14 cups of raw broccoli daily. While it is important to encourage eating foods rich in natural folate, this advice should also be a complement to mandatory fortification rather than a substitute for it.
Currently, only 54 countries require folic acid to be added to at least one kind of flour. These countries report a 30 to 70 percent decline in NTDs as a result. We need urgently to increase the pace at which mandatory folic acid fortification programs are implemented so that we can prevent all the deaths and disability from folic acid-preventable spina bifida and anencephaly.
Oman was the first country to fully implement a program to fortify flour with folic acid to prevent NTDs. That was in 1996, and in the following 15 years, we have enough evidence to prove that fortifying flour with folic acid effectively prevents NTDs. Let’s celebrate the progress and prevent all cases of folic acid-preventable spina bifida and anencephaly by 2015.
See more information on the 15-year history of fortifying flour with folic acid.
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